Vaccines can cause strabismus and neurological disorders

Page 11: Paralysis of the 7th cranial nerve A baby, 3 months old, after 2 days from the anti-pneumococcal (Prevenar), has presented a not well defined diffused cutaneous manifestation. Since then, the mother has reported irritability and lack of appetite. Later (7 days after vaccination) the mother known, especially during crying, inability to close the left eye and deviation at the bottom of the corner of the mouth, so it brings the child into pediatric acceptance. There are small point outbreaks that are detected in the lower limbs. The child is periodically monitored in the hospital and, after 4 months from the onset, the symptoms are still present even if decreased in intensity. In the literature anecdotal cases of paralysis of the seventh cranial nerve are described following the administration of hepatitis B vaccines, oral polio and influenza without evidence of causal correlation (11,12,13,14), and were not found by us in databases national and international (Pub Med), cases related to the administration of Prevenar. Link: http://www.epicentro.iss.it/temi/vaccinazioni/pdf/Reavac_2002-2005_MO.pdf T he facial nerve is one of 12 cranial nerves that emerge directly from the brain. Marked as a cranial nerve 7 (VII), the facial nerve exits the brain, emitting branches along its way to the parotid gland where it splits into five smaller nerves. Tell anyone who you know who could still get vaccinated to scrutinize their child's face before and after the next round of vaccines, looking for any unilateral changes - an eye moved to one side, a lowering of one side of the mouth; anything - even an eye that flashes slightly in sync with each other. Could it be a vaccine injury, I bet your pediatrician always warns you before a vaccination is right? THIRD PARALYSIS OF THE CRANIAL NERVES A study of the Journal of Pediatrics in Italy is entitled Paralysis of the third partial nerve after vaccination against measles mumps and states: "MMR viruses are neurotropic, therefore, although the vaccine is obtained from live attenuated viruses, vaccination can produce disorders neurological. "An example, a" 20-month-old Italian boy (below) who received a dose of MMR (VAX PRO) vaccine according to the normal vaccination program. "

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Abstract

Background

Measles Mumps Rubella (MMR) vaccination is known to cause some serious adverse events, such as fever, rash, gland inflammation and neurologic disorders. These include third and sixth cranial nerve palsies.

Results

The case reported describes a partial recurrent oculomotor palsy associated with systemic symptoms following MMR vaccination in a healthy young child. The oculomotor palsy did not recover completely during the follow-up.

Conclusions

Most of the times, measles, mumps and rubella cause mild illness and discomfort; but can also have serious or fatal sequelae. MMR vaccination has been proved to be safe and to reduce significantly the number of reported infections due to these viruses. However, significant adverse events can occur and paediatricians and public health operators should be aware of this aspect.

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Partial third nerve palsy after Measles Mumps Rubella vaccination

Sir,

Measles Mumps Rubella (MMR) vaccination is known to cause some serious adverse events. These can include fever, rash, gland inflammation and neurologic disorders like epilepsy, encephalitis, aseptic meningitis and autistic disorders [1,2].

The case reported below describes a partial recurrent oculomotor palsy following MMR vaccination in a healthy young child.

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Case Report

A 20-month-old Italian boy received a MMR (MMR VAX PRO®) vaccine dose according to the normal vaccination schedule. Twenty days later he presented fever and cutaneous rash, which resolved spontaneously in one day, and left eye (LE) eso-hypotropia, which also lasted 24-48 hrs until complete self-recovery. This episode recurred 20 days later: the ophthalmological examination showed a deficit of elevation in adduction of the LE and was diagnosed as "acquired palsy of the inferior oblique muscle" [Fig. ​[Fig.1].1]. The remaining neurologic examination was normal. EEG, brain MRI with and without gadolinium, blood count, blood chemistry were normal. Serum titres against main viral agents (Citomegalovirus, Epstein-Barr, Herpes Simplex, Varicella Zoster, Papovavirus B19, Influenza, Parainfluenza, Respiratory Syncytial) were negative, except for a positive IgG titre for Rubella virus. A week later the symptoms partially disappeared without any treatment. The following scheduled neurological controls continued to be normal, while the orthoptic examination showed persisting, but inconstant, weakening of LE inferior oblique muscle function. At the last control, when the child was 5 years old, visual acuity and stereopsis tests were normal, but a mild deficit of the inferior oblique muscle function persisted, with orthophoria in primary position.

Discussion

MMR viruses are neurotropic. Therefore, although the vaccine is obtained by live attenuated viruses, vaccination may produce neurological disorders. Only a few cases of benign, recurrent cranial nerve palsies, secondary to immunization, have been described. Patients with complete palsy of the third [3] or sixth [4-7] cranial nerve have been reported. In our case, the oculomotor nerve palsy is incomplete i.e. only the inferior oblique muscle is involved in one eye. The previously reported cases resolved spontaneously and completely within several months. In our case, however, a mild deficit of the muscle has persisted several years following vaccination and may be considered permanent.

In conclusion, public confidence in immunization must be maintained because safety and efficacy of MMR vaccination is clearly demonstrated; however potential adverse events must be strictly and carefully monitored.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944153/